Issue 09

What the evolution of scientific methods says about their future.

Since launching in 1869, Nature has evolved from a periodical offering commentary on pigeons to the prestige journal in science. But how did Nature build its reputation, and can it last?

Clinical trials are engines for scientific discovery. Better drugs require not just more trials, but also improved data collection, to create therapeutic feedback loops.

A biological puzzle that made one researcher and ruined another might never be solved.